Synthesis of (+)-aptosimon, a 4-oxofurofuran lignan, by erythro selective aldol condensation and stereoconvergent cyclization as the key reactions.

نویسندگان

  • Satoshi Yamauchi
  • Munetoshi Yamaguchi
چکیده

The 4-oxofurofuran lignan, (+)-aptosimon (1), was synthesized from gamma-butyrolactone (9). To construct the two benzylic chiral center of (+)-aptosimon (1), highly erythro selective aldol condensation and stereoconvergent SN1 intramolecular cyclization were used as the key reactions.

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عنوان ژورنال:
  • Bioscience, biotechnology, and biochemistry

دوره 67 4  شماره 

صفحات  -

تاریخ انتشار 2003