Synthesis of (+)-aptosimon, a 4-oxofurofuran lignan, by erythro selective aldol condensation and stereoconvergent cyclization as the key reactions.
نویسندگان
چکیده
The 4-oxofurofuran lignan, (+)-aptosimon (1), was synthesized from gamma-butyrolactone (9). To construct the two benzylic chiral center of (+)-aptosimon (1), highly erythro selective aldol condensation and stereoconvergent SN1 intramolecular cyclization were used as the key reactions.
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عنوان ژورنال:
- Bioscience, biotechnology, and biochemistry
دوره 67 4 شماره
صفحات -
تاریخ انتشار 2003